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EpiCast Report: Graft-Versus-Host Disease - Epidemiology Forecast to 2023

SKU:GDHCER064-14 / 403481
Publication Date:01.07.2014
Language version:English
Format:PDF
Report Type:Zukunftsanalyse
Lieferzeit:2-3 Tage
Nr of pages:56 pages
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- The Graft-Versus-Host Disease (GVHD) EpiCast Report provides an overview of the risk factors, comorbidities, and the global and historical trends for the diagnosed incidence of hematopoietic stem cell transplantations (HSCTs) (including first, multiple, and re-transplants), segmented by transplant type (autologous and allogeneic), and the diagnosed incident cases of GVHD in the six major markets (6MM) (US, France, Germany, Italy, Spain, and UK). GlobalData epidemiologists also forecast the four-year diagnosed prevalent cases of acute GVHD (aGVHD) and the five-year diagnosed prevalent cases of chronic GVHD (cGVHD) in the 6MM.
- The GVHD epidemiology report is written and developed by Masters- and PhD-level epidemiologists.
- The EpiCast Report is in-depth, high quality, transparent and market-driven, providing expert analysis of disease trends in the 6MM.


- Develop business strategies by understanding the trends shaping and driving the global GVHD market.
- Quantify patient populations in the global GVHD market to improve product design, pricing, and launch plans.
- Organize sales and marketing efforts by identifying the groups that present the best opportunities for GVHD therapeutics in each of the markets covered.
- Identify the number of incident and prevalent aGVHD and cGVHD cases.

Content of the report

Graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT) that occurs when the donated (graft) cells are rejected and attack the host’s cells as foreign. GVHD can progress from mild to severe forms as either acute GVHD (aGVHD) or chronic GVHD (cGVHD). Both aGVHD and cGVHD commonly affect organs such as the skin, gastrointestinal (GI) tract, liver, oral mucosa, and eyes.

GlobalData epidemiologists forecast an increase in the diagnosed incident cases of aGVHD in the 6MM, from 8,062 diagnosed incident cases in 2013 to 11,568 diagnosed incident cases in 2023, at an Annual Growth Rate (AGR) of 4.35% during the forecast period. Similarly, GlobalData epidemiologists forecast an increase in the diagnosed incident cases of cGVHD in the 6MM, from 7,359 diagnosed incident cases in 2013 to 10,485 diagnosed incident cases in 2023, at an AGR of 4.25% during the forecast period.

To forecast the diagnosed incident cases of aGVHD and cGVHD in the 6MM, GlobalData epidemiologists selected nationally-representative studies that provided the diagnosed incidence of aGVHD and cGVHD using the uniform validated diagnostic criteria and classification defined by the Center International Blood and Marrow Transplant Research standard grading system for aGVHD, and the standard criteria for cGVHD. In this analysis, GlobalData epidemiologists provided detailed, clinically relevant segmentations for the diagnosed aGVHD and cGVHD cases. Another strength of this analysis is that the same methodology was used across the 6MM, thereby allowing for meaningful global comparisons of the diagnosed incident GVHD cases.
 
Graft-versus-host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (HSCT) that occurs when the donated (graft) cells are rejected and attack the host’s cells as foreign. GVHD can progress from mild to severe forms as either acute GVHD (aGVHD) or chronic GVHD (cGVHD). Both aGVHD and cGVHD commonly affect organs such as the skin, gastrointestinal (GI) tract, liver, oral mucosa, and eyes (Hymes et al., 2012). The global distribution of GVHD is directly dependent on transplantation-related factors, including the donor type, the age of the donor and the recipient, the sex parity between the recipient and the donor, the pre-transplantation conditioning regimen, and the use of GVHD prophylaxis pre- and/or post-transplantation. Around 30–70% of HSCT recipients will develop aGVHD, and another 30–70% will develop cGVHD independent of aGVHD (Arora et al., 2011; Champlin et al., 2000; Hymes et al., 2012; Jagasia et al., 2012; Joseph et al., 2008; Przepiorka et al., 1999). GVHD can be unpleasant and reduces the quality of life following HSCT, and in severe forms, significantly increases the risk of non-relapse mortality (Hymes et al., 2012; Wood et al., 2013). The number of persons with GVHD will continue to increase with the increase in survival of patients with GVHD and the increase in the number of patients who are at risk of developing aGVHD and cGVHD due to the increase in the number of allogeneic HSCTs performed worldwide (Joseph et al., 2008; Lee et al., 2003; Wood et al., 2013).

This report provides an overview of the risk factors, comorbidities, and the global and historical trends for the diagnosed incidence of HSCTs (including first, multiple, and re-transplants), segmented by transplant type (autologous and allogeneic), and the diagnosed incidence of GVHD in diagnosed incident cases of first HSCTs in the six major markets (6MM) (US, France, Germany, Italy, Spain, and UK). GlobalData epidemiologists also provide a forecast for the four-year diagnosed prevalent cases of aGVHD and the five-year diagnosed prevalent cases of cGVHD in the 6MM. To forecast the diagnosed incident cases of HSCTs and the diagnosed incident and diagnosed prevalent cases of GVHD in the 6MM, GlobalData epidemiologists selected nationally-representative, population-based studies that provided the diagnosed incidence and the overall survival (OS) rates for HSCTs and GVHD in the 6MM.

GlobalData epidemiologists forecast an increase in the diagnosed incident cases of aGVHD in the 6MM, from 8,062 diagnosed incident cases in 2013 to 11,568 diagnosed incident cases in 2023, at an Annual Growth Rate (AGR) of 4.35%, during the forecast period. In 2023, the US will have the highest number of diagnosed incident cases of aGVHD in the 6MM, with 4,989 diagnosed incident cases, whereas Spain will have the lowest number of diagnosed incident cases of aGVHD, with 704 diagnosed incident cases.

Similarly, GlobalData epidemiologists forecast an increase in the diagnosed incident cases of cGVHD in the 6MM, from 7,359 diagnosed incident cases in 2013 to 10,485 diagnosed incident cases in 2023, at an AGR of 4.25% during the forecast period. In 2023, the US will have the highest number of diagnosed incident cases of cGVHD in the 6MM, with 4,425 diagnosed incident cases, whereas Spain will have the lowest number of diagnosed incident cases of cGVHD, with 648 diagnosed incident cases. GlobalData epidemiologists held the diagnosed incidence of aGVHD and cGVHD constant throughout the forecast period; therefore, changes in the diagnosed incidence of allogeneic HSCTs in the respective markets, in combination with population changes, are driving the increase in the diagnosed incident cases of aGVHD and cGVHD.