Veterinary Health Markets

Profound changes are happening in the animal health market. Pet owners in the United States are demanding more advanced and expensive treatments for companion animals, driving growth in the companion-animal sector. At the same time, concerns about livestock health care and feeding are driving changes in industrial animal husbandry. This TriMark Publications report offers a broad, yet detailed, overview of the shape of the veterinary health products market over the next several years. Examining both livestock and companion-animal markets. The overall market for veterinary therapeutics and diagnostic products has grown dramatically. This report analyzes the U.S. veterinary pharmaceuticals and diagnostics markets. The report outlines market size, market growth, forecasts, and competitive information. Focusing both on companion (pet) animal markets and agricultural livestock, the report examines the markets for pharmaceuticals, vaccines, diagnostics, and feed additives. The study reveals: the size of the markets for companion-animal products, broken down by type of animal (i.e., cats, dogs, small animals, etc.); size of the markets for livestock products; how the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) regulations impact these markets; the identity of the top market players, along with their market shares and future prospects; how the antibiotic feed additive controversy is influencing the agricultural market; and key players in the veterinary pharma and diagnostic markets.
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1. Overview 7
1.1 Objective of Report 7
1.2 Scope of Report 7
1.3 Methodology 8
1.4 Executive Summary 9

2. Veterinary Biological Products 11
2.1 Overview of Health Products Market 11
2.1.1 World Products Markets 11
2.1.2 U.S. Animal Health Products Market 14
2.1.3 European Animal Health Markets 15
2.1.4 Asian Animal Health Products Markets 16
2.1.5 World Market Share 23
2.1.6 Common Animal Diseases 24
2.1.7 Companion Animals 54
2.2 Veterinary Vaccines 57
2.2.1 Major Canine Vaccines 59
2.2.2 Major Feline Vaccines 61
2.3 Agricultural Animals 67
2.3.1 Major Cattle Vaccines 69
2.3.2 Major Poultry Vaccines 74
2.3.3 Major Sheep Vaccines 81
2.3.4 Major Swine Vaccines 83
2.3.5 Major Equine Vaccines 88
2.4 Trends in the Biologicals Market 91
2.5 Nutraceuticals 93
2.5.1 Nutraceutical Market for Companion Animals 94
2.6 OTC Animal Health Global Market Opportunity 97

3. Veterinary Pharmaceutical Products 98
3.1 Overview 98
3.1.1 Pharmaceutical Products for Dogs and Cats 103
3.1.1.1 Antiparasitics 107
3.1.1.2 Antibiotics 109
3.1.1.3 Anti-Inflammatories 112
3.1.1.4 Chronic Care Products 115
3.1.1.5 Cardiovasculars 116
3.1.1.6 GI Products 116
3.1.1.7 Endocrine Products 117
3.1.1.8 Anti-Infectives 118
3.1.1.9 Behavior Modifiers 119
3.1.1.10 Anthelminitics 119
3.1.1.11 Antifungals 120
3.1.1.12 Cancer and Chemotherapy in Companion Animals 120
3.1.2 Pharmaceutical Products for Agricultural Animals 130
3.1.2.1 Antiparasitics 130
3.1.2.2 Antibiotics 131
3.1.2.3 Insecticides 133
3.2 Leading Products and Competitors 133
3.2.1 Elanco 133
3.2.2 Novartis 134
3.2.3 Alpharma 135
3.2.4 Pfizer Animal Health 136
3.3 Veterinary Pharmaceutical Market Trends 137
3.4 Companion-Animal Crossover Products 138
3.5 Generics in the Animal Health Sector 139

4. Veterinary Feed Additive Products 141
4.1 Overview 141
4.2 U.S. Feed Additives Market 146
4.3 Leading Feed Additives and Competitors 146
4.4 Feed Additives Market Trends 148
4.4.1 Livestock Performance Enhancers 149
4.5 Pet Food Additives and Contaminants 151

5. Veterinary Diagnostic Test Products 153
5.1 Introduction 153
5.2 Veterinary Diagnostic Market Size and Growth Rates 155
5.2.1 Market Drivers 158
5.2.2 Immunodiagnostic and Nucleic Acid Testing Markets 158
5.2.2.1 Market Size and Growth 158
5.2.3 Technological Developments in the Diagnostic Industry 158
5.3 Competitive Situation 160
5.4 Estimate of Units Sold and Pricing 161
5.5 PCR Applications for Veterinary Use 161
5.6 Companion-Animal Diagnostics 165
5.6.1 Feline Leukemia Virus 165
5.7 Agricultural Animal Diagnostics 166
5.8 U.S. Diagnostic Test Market 167
5.9 Leading Competitors in Diagnostic Testing 168
5.10 Veterinary Diagnostic Market Trends 171
5.11 Collaborative Licensing 172
5.12 BSE Diagnostic Tests 172
5.13 West Nile Virus Diagnostic Tests 173
5.14 Avian Flu Diagnostic Tests 173

6. Overview of the Veterinary Health Market 174
6.1 Regulatory Environment 174
6.1.1 International Bodies for Regulation of Animal Health Products 175
6.1.1.1 Regulation of Animal Health Products in the E.U. 177
6.1.1.2 Regulation of Animal Health Products in the U.S. 179
6.1.1.3 Regulation of Animal Health Products in Japan 180
6.2 The European Animal Health Industry 181
6.2.1 Trends Driving Demand 181
6.2.1.1 European, International and U.S. Oversight of Veterinary Medicines 181
6.2.1.2 Antibiotic Usage 182
6.3 Mergers and Acquisitions 182
6.4 New Product Launches 184
6.5 Bioterrorism and Foodborne Pathogens™WHO Guidelines 185
6.5.1 The U.S. Bioterrorism Preparedness and Response Act, 2002 185
6.6 Generic Products 186

7. Emerging Markets 188
7.1 Biotechnology and Veterinary Health 188
7.1.1 Biotechnology and Biologics 188
7.1.1.1 Recombinant DNA Vaccines 188
7.1.1.2 Plant-derived Vaccines 189
7.1.2 DNA Probes 189
7.1.3 Biotechnology and Pharmaceuticals 190
7.1.3.1 Immunodiagnostic Applications 190
7.1.3.2 Growth Enhancers 191
7.2 Impact of Genomics on Veterinary Health 191
7.2.1 Autosomal Dominant Traits 194
7.2.2 X-Linked Traits 194
7.2.3 Autosomal Recessive Traits 195
7.2.4 Current DNA Testing in Animals 196
7.2.5 Direct DNA Testing: Mutation-based Tests 197
7.2.6 Indirect DNA Testing: Linkage-based or Marker-Based Tests 197
7.3 Companion-Animal Markets 197
7.4 Alternative Medicine in Veterinary Practice 198
7.5 Generics in the Animal Health Market 198
7.6 Pet Insurance 204
7.7 Orthotics and Prosthetics for Animals 207
7.8 Pet Cloning 210

8. Company Profiles 212
8.1 Abaxis, Inc. 212
8.2 Abbott Laboratories 214
8.3 Adiagene 214
8.4 Agricultural Research Service 215
8.5 Alpharma, Inc. 215
8.6 Avian Biotech 217
8.7 BASF 217
8.8 Bayer Animal Health 218
8.9 Biobest Laboratories 219
8.10 Biocurex 220
8.11 BioVet, Inc. 220
8.12 Boehringer Ingelheim Corp. 221
8.13 CEVA Sant™ Animale 221
8.14 CJ Corporation 223
8.15 Cypress Diagnostics 223
8.16 Dabaco Viet Nam Corporation 225
8.17 DayMoon Industries, Inc. 225
8.18 Dow AgroSciences LLC 225
8.19 Dupont Qualicon 226
8.21 Egyptian International Pharmaceutical Industries Company 227
8.22 Elanco Animal Health 227
8.23 Eurofins Medigenomix GmbH 228
8.24 Eurovet 228
8.25 Gene Check, Inc. 229
8.26 Heska 229
8.27 Huvepharma 230
8.28 IDEXX Laboratories, Inc. 230
8.29 IWAKI & Co., Ltd. 232
8.30 Janssen Pharmaceutica 232
8.31 Laboklin 233
8.32 Medika d.d. 234
8.33 Merck 234
8.34 Merial 236
8.35 MetaMorphix, Inc. 238
8.36 Microbix Biosystems, Inc. 239
8.37 Momina krepost AD Veliko Tarnovo 239
8.38 Mosaic Company 240
8.39 Neogen Corporation 241
8.40 Norbrook Laboratories Ltd. 242
8.41 Novartis Animal Health 243
8.42 OptiGen 244
8.43 Orion Corporation 245
8.44 PETCO Animal Supplies, Inc. 246
8.45 PetSmart, Inc. 246
8.46 Pfizer Animal Health 247
8.47 Phibro Animal Health Corporation 254
8.48 Phylaxia 1912 Holding NyRt 254
8.49 Prionics 254
8.50 Randox 254
8.51 Sanofi-Aventis 255
8.52 Skystar Bio-Pharmaceutical Company 256
8.53 Sunwin International Nutraceuticals 257
8.54 Synbiotics Corporation 257
8.55 Teva Pharmaceutical Industries Ltd. 258
8.56 The Arab Pesticides and Veterinary Drugs Mfg. Co. 258
8.57 ThermoGenesis Corp. 259
8.58 VCA Antech, Inc. 259
8.59 Velefarm ad Beograd 261
8.60 Veterinarski Zavod Subotica ad Subotica 261
8.61 V™toquinol 261
8.62 Virbac SA 261
8.63 WooGene B&G Co., Ltd 262

9. Business Trends in the Industry 263
9.1 Animal Health Additive Growth Trends 263
9.2 Move to Complete Product Portfolio 263
9.3 Reduced Antibiotic Usage in Animal Feeds 263
9.4 European Animal Health Industry 263
9.5 Licensing and Partnership Opportunities in Animal Health R&D 264

10. Company Directory 265

Appendix 1: Dosages for Selected Drugs Alphabetical Listing 274
Appendix 2: Trade Names 287
Appendix 3: Abbreviations 299
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INDEX OF FIGURES

Figure 2.1: Global Animal Health Market by Product Category, 2008 11
Figure 2.2: Worldwide Sales of Animal Health Products by Product Class, 2008 12
Figure 2.3: Worldwide Animal Health Industry Revenues by Species, 2008 13
Figure 2.4: Worldwide Animal Health Products Market by Region, 2008 13
Figure 2.5: Market Share for the Top Ten Animal Health Companies, 2008 14
Figure 2.6: U.S. Companion Animal Healthcare Products Share of Overall Animal Health Product Sales, 2008 15
Figure 2.7: Pet Population in Japan, 2006 and 2008 17
Figure 2.8: Swine Population in Japan, 2006-2008 18
Figure 2.9: Cattle Population in Japan, 2006-2008 19
Figure 2.10: The Indian Biologicals Industry by Product Category, 2007 21
Figure 2.11: Global Incidence of Avian H5N1, 2010 76
Figure 2.12: Global Outbreaks of Equine Viral Arteritis, 2009 91
Figure 3.1: Animal Health Product Sales in the U.S., 2005-2014 102
Figure 3.2: The European Parasiticide Market by Product Category, 2008 109
Figure 3.3: Growth in Global Sales of Antibiotic Products, 2005-2012 132
Figure 4.1: Global Market for Livestock Performance Enhancers, 2007 151
Figure 5.1: Growth of the Lateral Flow Diagnostic Tests in the Veterinary Market, 2005-2015 160
Figure 7.1: The U.S. Market for Animal Pharmaceuticals, 2012 198
Figure 7.2: U.S. Animal Pharmaceuticals: Percentage of New Generics, 2010 201
Figure 7.3: U.S. Market for FDA-approved Pharmaceuticals for Companion Animals, 2008 202


LIST OF TABLES

Table 2.1: World Market for Animal Health Products, 2002-2012 11
Table 2.2: Global Sales of Animal Health and Nutrition Products, 2004-2012 12
Table 2.3: Worldwide Animal Health Products Market by Region, 2008 13
Table 2.4: U.S. Animal Health Product Sales, 2005-2014 14
Table 2.5: Animal Health Market: Sales Statistics™Europe, 2008 16
Table 2.6: E.U. Animal Health Market, 2004-2015 16
Table 2.7: Japanese Animal Health Market, 2000-2012 17
Table 2.8: Chinese Animal Health and Nutrition Market, 2005-2012 19
Table 2.9: Indian Animal Health Market, 2003-2012 20
Table 2.10: Institutions Involved in Manufacturing Vaccines and Other Biological Products for Livestock 22
Table 2.11: Worldwide Animal Health Product Sales for Leading Producers, 2009 23
Table 2.12: Common Animal Diseases 25
Table 2.13: Cattle Diseases 25
Table 2.14: Sheep and Goat Diseases 26
Table 2.15: Equine Diseases 26
Table 2.16: Swine Diseases 26
Table 2.17: Avian Diseases 27
Table 2.18: Fish Diseases 27
Table 2.19: Other Infectious Diseases 27
Table 2.20: U.S. expenditure on pet products and services, 1994-2010 55
Table 2.21: Estimated Pet Product Sales, by Category, within the U.S. Market, 2010 55
Table 2.22: Worldwide Veterinary Vaccine Market, 2005-2012 57
Table 2.23: U.S. Veterinary Vaccine Market, 2004-2013 58
Table 2.24: Second-Generation Licensed/Commercialized Veterinary Viral Vaccines 59
Table 2.25: Canine Vaccinations 61
Table 2.26: Dog Vaccine Price List 61
Table 2.27: American Association of Feline Practitioners Feline Vaccination Guidelines 62
Table 2.28: Recently Commercialized Veterinary Bacterial Vaccines 67
Table 2.29: Available Veterinary Live Protozoal Vaccines 68
Table 2.30: Available Veterinary Killed/Subunit Protozoal Vaccines 68
Table 2.31: Commercialized Reproduction Control Vaccines 68
Table 2.32: Global Market for Nutraceutical in Companion Animals, 2005-2012 96
Table 3.1: Veterinary Drugs Listed by Therapeutic Class 98
Table 3.2: Sales of Pharmaceutical Products for Animal Health in the U.S., 2002-2012 103
Table 3.3: Number of Dogs in the U.S., 1996-2009 104
Table 3.4: Number of Cats in the U.S., 1996-2009 104
Table 3.5: Number of Companion Animals by Country, 2009 104
Table 3.6: American Veterinary Specialists 106
Table 3.7: Companion-Animal Products Sales, 2009 107
Table 3.8: U.S. Antiparistic Animal Health Product Sales, 2005-2012 107
Table 3.9: Global Antiparistic Animal Health Product Sales, 2005-2012 108
Table 3.10: Worldwide Sales of Animal Health Antibiotics, 2005-2014 109
Table 3.11: U.S. Sales of Animal Health Antibiotics, 2005-2014 110
Table 3.12: European Sales of Animal Health Antibiotics, 2005-2012 110
Table 3.13: Common Veterinary Anti-Inflammatories 113
Table 3.14: U.S. Pet Anti-Inflammatory Market, 2003-2012 114
Table 3.15: Retail Pricing of Rimadyl 114
Table 3.16: EtoGesic Pricing 114
Table 3.17: Therapy for Various Pet Cancers 121
Table 3.18: Mechanisms of Action, Indications and Toxicities of Selected Antineoplastic Agents 124
Table 3.19: Treatment Options for Canine or Feline Lymphomas 126
Table 3.20: Chemotherapeutic Agents Commonly Used in Veterinary Medicine, and the Associated Risks 128
Table 3.21: Bacterial and Protozoal Threats to Poultry 132
Table 3.22: Bacterial and Protozoal Threats to Pigs 133
Table 3.23: Elanco Veterinary Products Summary 134
Table 3.24: Schering-Plough Products Acquired by Pfizer Animal Health, 2008 136
Table 3.25: Fort Dodge Animal Health Products Acquired by Pfizer in 2009 137
Table 4.1: Global Sales of Feed Additives for Animal Health, 2005-2014 141
Table 4.2: Target Species and Brand Names for Probiotics 145
Table 4.3: Feed Additives: Antimicrobials and Growth Promotants 147
Table 4.4: Feed Additives: Anthelmintics 147
Table 4.5: U.S. Beef Exports, 2002-2008 147
Table 4.6: Retail Equivalent Value of U.S. Beef Industry, 2002-2008 147
Table 4.7: U.S. Beef Consumption, 2002-2008 148
Table 4.8: Use of Antibiotics as Growth Promotants 149
Table 4.9: Global Market for Livestock Performance Enhancers, 2004-2012 150
Table 5.1: Veterinary Diagnostics World Market, 2005-2012 155
Table 5.2: Veterinary Immunodiagnostic Testing World Markets, 2005-2012 158
Table 7.1: Labs That Perform Canine DNA Testing 194
Table 7.2: DNA (Mutation) Tests for Canine Inherited Diseases 195
Table 7.3: DNA (Marker) Tests for Canine Inherited Diseases 196
Table 7.4: Companies Producing Generic Pharmaceuticals for Animal Health 200
Table 7.5: Generics vs. Branded Animal Health Pharmaceuticals, 2010 201
Table 7.6: U.S. Animal Health Generic Pharmaceuticals in the Pipeline, 2010 203
Table 7.7: Veterinary Insurance Rates and Coverage for Dogs in the U.S., 2010 206
Table 7.8: Average Initial Claims for Common Medical Conditions in Pets, 2010 207
Table 8.1: Pfizer Animal Health Products 250
Table 8.2: Pfizer Products Patents 251
Table 8.3: Key Pfizer Animal Health Products 253
Table 8.4: Pfizer Livestock Products 253
Table 8.5: Pfizer Equine Products 253
Table 8.6: Pfizer Companion Animal Products 254
Table 9.1: European Animal Health Market Sales, 2005-2012 264
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